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Small Intestinal Fungal Overgrowth, or SIFO and Its Role in Autoimmune Disease, Testing, Symptoms, and Treatment Options


Understanding your gut health can feel overwhelming, especially when facing conditions like SIFO (Small Intestinal Fungal Overgrowth) and SIBO (Small Intestinal Bacterial Overgrowth). These conditions often overlap and can worsen a series of symptoms that affect your daily life.


As research deepens our understanding of their link to autoimmune diseases, it becomes crucial to explore how they function, the symptoms they produce, and the treatment options available.



What is Small Intestinal Fungal Overgrowth, or SIFO?


SIFO, or Small Intestinal Fungal Overgrowth, occurs when there is an excessive growth of fungi, primarily yeast, in the small intestine. This condition can give rise to a range of gastrointestinal issues. Though it may not be as widely recognised as SIBO, SIFO carries similar risks and symptoms that can impact your health.


Fungi, particularly strains like Candida albicans, thrive under certain conditions within our bodies. When the balance of microorganisms is disrupted—such as after a course of antibiotics—it can lead to overgrowth. This imbalance not only triggers inflammation but also impacts gut health and overall well-being.


To visualise SIFO, think of your gut as an ecosystem. Like any ecosystem, it requires a balance of organisms to thrive. A surplus of harmful fungi disrupts this balance, potentially leading to numerous health complications.



The Link Between SIFO and SIBO


SIFO is often linked with SIBO due to their overlapping symptoms and shared role in disrupting gut health. SIBO involves an abnormal increase of bacteria in the small intestine, while SIFO indicates an excess of fungal organisms. Those experiencing SIBO may also show symptoms related to SIFO.


For instance, studies have shown that about 30% of patients with SIBO also have SIFO. When SIBO is untreated, it can create an environment favorable for fungi to flourish, especially after antibiotic treatment that wipes out beneficial bacteria.

Recognising this connection is key. Both conditions can lead to systemic inflammation and are increasingly seen as potential triggers for autoimmune diseases, which occur when the immune system mistakenly attacks the body’s own tissues.


abdominal pain candida

Common Symptoms of SIFO


Identifying the symptoms of SIFO is essential, as they can closely resemble those of SIBO, potentially complicating diagnosis. Here are some common symptoms to keep in mind:


  • Bloating: Many people report a feeling of fullness and discomfort in the abdomen, often underlining their gut struggles.


  • Gas and Flatulence: Excess gas production often results from fermentation processes in the gut, which can lead to embarrassing situations in social settings.


  • Diarrhea or Constipation: Fluctuations between diarrhea and constipation can indicate disturbances in gut flora. Studies estimate that over 40% of individuals with gut issues face irregular bowel movements.


  • Fatigue: Chronic tiredness can stem from nutrient malabsorption, which is a common result of both SIFO and SIBO.


  • Brain Fog: Cognitive difficulties, often linked to digestive health, can lead to challenges in maintaining focus and clarity.


Being aware of these symptoms can urge you to seek further evaluation, particularly if you notice a combination of these issues.



Limited Testing Options for SIFO


Testing for SIFO poses its challenges due to the scarcity of specific tests. One common method is organic acid testing, which measures by-products in your urine that may indicate fungal overgrowth. However, this test does not exclusively target the small intestine, making it less definitive for SIFO.


This gap highlights the need for specialised testing, especially for those suspecting fungal overgrowth. Many healthcare professionals may prioritise conditions like SIBO due to a lack of awareness surrounding SIFO, leading to missed opportunities for proper diagnosis.




The Role of the Low Candida Diet


If you’re considering treatment for SIFO, adopting a Low Candida Diet may be beneficial. This dietary plan focuses on cutting back on sugar and refined carbohydrates, which can contribute to yeast overgrowth.


The dietary approach emphasises whole foods, including:


  • Vegetables: Non-starchy options, like leafy greens and bell peppers, provide vital nutrients without feeding harmful fungi.


  • Lean Proteins: Including meats, poultry, and fish supports tissue repair and boosts immunity.


  • Healthy Fats: Foods such as avocados, olive oil, and nuts are important for maintaining cellular health.

    low candida diet for sifo

In addition to dietary adjustments, some herbs can effectively combat SIFO. Herbal antif-ungals, like oregano oil and grapefruit seed extract, have demonstrated potential in managing fungal overgrowth; however, it's important to consult with a healthcare provider when considering herbal treatments.



Natural Treatments for SIFO


Herbal remedies can be highly effective in addressing Small Intestinal Fungal Overgrowth (SIFO) and Candida overgrowth by inhibiting fungal growth, reducing biofilm formation, and restoring balance in the gut microbiota.

Key anti=fungal herbs include:


  • Oregano oil, which contains carvacrol and thymol, potent compounds known for their ability to combat fungal infections, and pau d’arco, a traditional antifungal with lapachol, which inhibits Candida species.


  • Berberine, found in herbs like goldenseal and barberry, exhibits both anti-fungal and antimicrobial properties while supporting gut integrity.


  • Garlic (Allium sativum), rich in allicin, disrupts Candida’s biofilm and hinders fungal replication.


  • Neem and caprylic acid (from coconut oil) are also useful for targeting fungal overgrowth while being gentle on beneficial gut bacteria.


herbs for small intestinal fungal overgrowth

Combining these herbs in a targeted protocol, alongside a low-sugar, anti-inflammatory diet, can effectively reduce fungal overgrowth and support gut health. Always use herbal treatments under professional guidance, as individual responses and interactions can vary.




Risk Factors for SIFO


Several factors can raise your risk of developing SIFO, and being aware of these can help you adopt preventative measures for better gut health. Key risk factors include:


  • Antibiotic Use: Long-term antibiotic treatments can disturb the natural balance of gut microorganisms, creating an environment conducive to fungal overgrowth.


  • Immune System Suppression: Individuals with compromised immune systems, such as those with autoimmune diseases, are more susceptible to SIFO.


  • Diabetes: Elevated blood sugar levels can foster conditions that support yeast growth, with studies indicating that nearly 70% of people with diabetes may have fungal issues.


  • Chronic Stress: Ongoing stress negatively impacts both gut health and immune function, which fosters an environment ripe for harmful organism overgrowth.


Recognising these risk factors can empower you to take proactive steps towards maintaining gut balance.



SIFO, SIBO, and Autoimmune Disease


Recent studies indicate that SIFO and SIBO may trigger or worsen autoimmune diseases. The gut microbiome significantly influences immune function, and disturbances in these ecosystems can lead to increased intestinal permeability, commonly known as "leaky gut."


When the gut barrier is compromised, the immune system may overreact to substances that would typically be harmless. This hyperresponsiveness can manifest as autoimmune conditions, prompting the body to attack its healthy tissues.


If you suspect you have an imbalance affecting your health, discussing both SIFO and SIBO with your healthcare provider should be part of your strategy.



The Expertise of Muriel Wallace-Scott and our team at The Autoimmune Clinic

Muriel Wallace-Scott

For anyone seeking help with SIFO or related gut health issues, consultation with a specialist can be invaluable. Muriel Wallace-Scott is a gut health expert and certified practitioner with a focus on SIBO. Her extensive knowledge about diagnosing and treating gastrointestinal issues makes her a trusted resource for tackling SIFO and SIBO.


Engaging with a specialist can lead to personalised treatment plans tailored to your unique health needs, making the journey to better gut health more

manageable.



Take Charge of Your Health


Identifying SIFO and its potential connection to autoimmune diseases is vital for improving your health. By recognising symptoms, understanding testing options, and exploring treatments like dietary changes and herbal remedies, you can regain control over your gut health.


As more individuals recognize the importance of their gut microbiome, addressing SIFO and its complications emerges as essential for achieving holistic health.


If you are experiencing symptoms linked to SIFO or SIBO, reach out for help from specialists like Muriel Wallace-Scott. They can help guide you toward practical strategies for enhancing your gut health and improving your overall quality of life.

SIBO doctor certified practitioner

Contact us on hello@autoimmunecliniclondon.com to find out more about how we can help you. Or book your complimentary discovery call below


 

About The Autoimmune Clinic

At the Autoimmune Clinic, we specialise in digestive disorders such as IBS, SIBO and IBD , through a functional medicine approach.


We go beyond symptom management to uncover and address the root cause of your condition, helping you regain control over your health and wellbeing.


Living with digestive symptoms can be overwhelming and impacting on day to day activities. That’s why our tailored programmes are designed to meet your unique needs, empowering you to take positive steps towards lasting health improvements.​​


About Muriel Wallace-Scott
She is a functional medicine practitioner and registered nutritional therapist. 

She is also a Kharrazian Institute Certified Practitioner, Shoemaker Proficiency Partner Diplomate, AIP Certified Health Coach as well as a SIBO Doctor Certified Practitioner.

She specialises in autoimmune disease, mould illness / CIRS, gut health, SIBO, MCAS and unexplained symptoms.

About Muriel Wallace-Scott

She is a functional medicine practitioner and registered nutritional therapist.

She is also a Kharrazian Institute Certified Practitioner, Shoemaker Proficiency Partner Diplomate, AIP Certified Health Coach as well as a SIBO Doctor Certified Practitioner.

She specialises in autoimmune disease, mould illness / CIRS, gut health, SIBO, MCAS and unexplained symptoms.



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